Angeliq ® contains both types of hormone (estrogen and progestogen), the level of which is reduced during menopause. Thus, it replaces the hormones that are not produced in the body. Climacteric period is characterized by the symptoms caused by a gradual decrease in the ovaries produce hormones. In addition, some women reduction of these hormones can lead to a decrease in bone density (postmenopausal osteoporosis).
Contained in the product Angeliq ® estradiol prevents or relieves painful symptoms (menopausal complaints) such as “hot flashes”, sweating, sleep disturbances, depressive moods, increased nervous irritability, dizziness, headaches, and involuntary urination, dryness and burning sensation in vagina, pain during sexual intercourse. Adding a progestogen (drospirenone) prevents the development of endometrial hyperplasia and cancer.
In addition, clinical studies confirmed decrease in bowel cancer risk in postmenopausal women.
Angeliq ® prevents bone loss caused by estrogen deficiency (postmenopausal osteoporosis).
In addition, due to the antiandrogenic properties of drospirenone Angeliq ® has a therapeutic effect on androgen disorders, such as acne (acne), seborrhea (skin lesion with the dysfunction of the sebaceous glands), androgenic alopecia (hair loss due to high levels of androgens).
Drospirenone also has anti-mineralocorticoid activity, increases the excretion of sodium and water, which can prevent high blood pressure, weight gain, edema, breast tenderness and other symptoms associated with fluid retention.
According to their biochemical and pharmacological profile of drospirenone similar to the natural progesterone produced by a woman’s body.
Angeliq ® also has a positive effect on blood lipid profile (for example, reduces the level of total blood cholesterol).
- Hormone replacement therapy (HRT) for menopausal disorders in postmenopausal women.
- Prevention of postmenopausal osteoporosis.
HRT is not recommended to start if any of the conditions listed below. If any of these conditions arise during HRT, you should immediately stop using the product.
- Pregnancy and lactation
- Bleeding from the vagina of unknown origin
- Confirmed or presumptive diagnosis of breast cancer
- Confirmed or presumptive diagnosis of hormone-dependent precancerous disease or hormone-dependent cancer
- Liver tumors present or in history (benign or malignant)
- Severe liver disease
- Severe kidney disease at present or in history (up to normalization of renal function)
- Acute arterial thrombosis or thromboembolism, including those leading to myocardial infarction, stroke
- Deep vein thrombosis in the acute stage, venous thromboembolism present or in history
- Severe hypertriglyceridemia
- Hypersensitivity to the drug Angeliq ® .
If any of these conditions occur in patients receiving Angelica, immediately discontinue use and consult your doctor
The use with caution
Angeliq ® should be used with caution in the following diseases: hypertension, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor), cholestatic jaundice or cholestatic pruritus during pregnancy, endometriosis, uterine fibroids, diabetes (see “Special Instructions”.) .
It should be appreciated that estrogens alone or in combination with progestins should be used with caution in the following diseases and conditions: smoking, hypercholesterolemia, obesity, systemic lupus erythematosus, dementia, gallbladder disease, thrombosis, retinal vessels, moderate hypertriglyceridemia, swelling in CHF, severe hypocalcemia, endometriosis, asthma, epilepsy, migraine, porphyria, liver hemangioma, hyperkalemia, a condition predisposing to the development of hyperkalemia, taking drugs that cause hyperkalemia – potassium-sparing diuretics, potassium drugs, ACE inhibitors, angiotensin II antagonists, and heparin receptors.
Pregnancy and lactation
HRT is contraindicated during pregnancy and lactation. . If pregnancy is detected during the reception of the drug Angelique, the drug should be immediately abolished.
Small amounts of sex hormones can be released from the mother’s milk.
Dosing and Administration
If you are taking estrogens or go to Angelique ® from another combined preparation for continuous reception, you can start treatment at any time. If you go to Angelique ® with a combined preparation for cyclical HRT should begin reception after the withdrawal bleeding.
Each package is designed for a 28-day reception.
Every day should take one anadrol 50 for sale coated. After receiving 28 anadrol 50 for sales from the current package, the next day, start a new pack Angeliq ® (continuous HRT), taking the first pill on the same day of the week as the first pill from the previous package.
The anadrol 50 for sale is swallowed whole with a little liquid. The time of day when you are taking a drug, it does not matter, but if you start to take the anadrol 50 for sales at any given time, you have to adhere to this time and beyond. Forgotten anadrol 50 for sale to drink as soon as possible. If it has been more than 24 hours after receiving the normal time, extra anadrol 50 for sale should be taken. When skipping a few pills may develop vaginal bleeding.
During the first few months of therapy may be a breakthrough bleeding and spotting. The frequency of bleeding decreases with the duration of therapy .. It is a common symptom, which is detected in about one in five women is breast pain.
|Systemic organ classes
(≥1 / 100 – <1/10)
(≥1 / 1000 and <1/100)
|Blood and lymphatic system
|The immune system
||Changes in weight (increase or decrease), anorexia, appetite increase, hyperlipidemia
||Depression, emotional lability, irritability
||Sleep disturbances, anxiety, decreased libido
||Paresthesia, impaired ability to concentrate, dizziness
|organ of vision
||eye diseases, visual disturbances
|The organ of hearing
|The cardiovascular system
||Palpitations, embolism, venous thrombosis, thrombophlebitis, arterial hypertension, migraine, varicose veins
|Liver, gastrointestinal tract
||Abdominal pain, nausea, abdominal enlargement
||Gastrointestinal disturbances, diarrhea, constipation, vomiting, dry mouth, flatulence, taste perversion, abnormal liver function tests indices
|Skin and subcutaneous tissue
||Diseases of the skin and hair, acne, alopecia, pruritus, rash, hirsutism
|Musculoskeletal system, connective tissue
||Pain in extremity, back pain, arthralgia, muscle spasms
|The kidneys and urinary system
||And urinary tract infections
|Reproductive system, mammary gland
||Benign tumors of the breast, breast enlargement, increased uterine fibroids, benign tumors of the cervix, menstrual irregularities, discharge from the genital tract
||Breast cancer, endometrial hyperplasia, benign tumors of the uterus, fibrocystic disease of the breast, uterus, ovary, cervix, pelvic pain, vulvovaginal disorders, vaginal candidiasis, vaginitis, vaginal dryness
|General disorders and local
||Asthenia, local edema
||Generalized edema, chest pain, malaise, excessive sweating
It reported the following adverse events in connection with taking HRT: nodosum or erythema multiforme, chloasma, purpura, pain and tension of the mammary glands, fatigue, intolerance to contact lenses.
If you think that on the background of Angelica you developed any side effects, even not included in this list, please send it to your doctor or pharmacist.
There were no risk of serious side effects when taking the drug in a random amount exceeding many times the daily therapeutic dose. Symptoms that may occur with overdose include nausea, vomiting, bleeding from the vagina. No specific antidote, treatment – symptomatic. In case of overdose, contact your doctor.
Interaction with other drugs
Always tell your doctor assigns you Angeliq ® , which medicines you are taking. Inform your doctor assign you other drugs that you are taking Angeliq ® . If you have any doubts about any of you used the drug, consult your physician.
Before the start of HRT use should be discontinued use of hormonal contraceptives. If necessary, check with your doctor contraception what contraception you can use.
Some medicines may reduce the effectiveness of the drug Angeliq ® . These include drugs used to treat epilepsy (e.g., hydantoin, barbiturates, primidone, carbamazepine) and tuberculosis (eg, rifampicin), antibiotics for the treatment of other infectious diseases (e.g., penicillin and tetracycline). Angeliq ® has no negative effect on glucose tolerance.
Excessive consumption of alcohol at the time of hormone replacement therapy with Angeliq ® has an impact on the effectiveness of the drug.
Prior to receiving the drug, and then at regular intervals during treatment (at least 1 time per year) should be done gynecological examination, including examination of mammary glands, blood pressure and other necessary research.
If hormone replacement therapy is carried out at one of the diseases or conditions listed below, you may need close medical supervision. Therefore, if you have found one of these conditions, tell your doctor before taking Angeliq ® .
you or any of your close relatives in the present or in history. The risk increases with age and reaches a maximum when:
– you or your relatives from kto-libo kogda-libo already had thrombosis of legs or lungs
– you have varicose veins
– you have excess body weight
– risk of deep venous thrombosis is temporarily increased in result of the operation, serious injury, or prolonged immobility. If you use Angeliq ® , tell your doctor about any planned hospitalization or surgical intervention (for 4-6 weeks).
- uterine fibroids;
- endometriosis, now or in the past;
- liver disease or gall bladder. After suffering a hepatitis use of the drug may not be earlier than 6 months (up to normalization of liver function);
- jaundice during previous pregnancy or previous use of sex hormones;
- hypertension (high blood pressure);
- chloasma (yellowish-brown pigment spots on the skin) in the present or in the past. If they are, avoid prolonged exposure to the sun or ultraviolet radiation;
- benign breast disease (breast);
- bronchial asthma;
- elevated blood triglyceride levels;
- systemic lupus erythematosus;
The following warnings related to the use of hormone replacement therapy should be considered when using the drug Angeliq ® .
Angeliq ® is not applicable for the purpose of contraception.
If necessary, the doctor will choose your contraception non-hormonal methods (with the exception of the calendar and temperature methods). If you suspect a pregnancy, you should stop taking the drug for as long as the pregnancy will not be excluded.
HRT and cancer
With prolonged use of estrogen alone, the probability of cancer uterine lining (endometrial cancer) increases. Progestogen used in the preparation Angeliq ® , prevents an increase in the risk.
Tell your doctor if the intake of Angeliq ® you are often violations of the cycle or breakthrough bleeding.
According to the results of clinical trials and observational studies have found an increase in the relative risk of developing breast cancer in women who use HRT for several years. The relative risk increases with duration, but may be missing or reduced in the treatment of estrogen only. This increase is comparable to the increase in delaying the onset of natural menopause, the risk of breast cancer in women each year, as well as obesity and alcohol abuse. The increased risk gradually decreases to normal levels during the first few years after stopping HRT.
HRT increases mammographic breast density, which in some cases may adversely affect the radiological detection of breast cancer.
In rare cases, the use of sex hormones observed the development of benign and even more rarely – malignant liver tumors. In some cases, bleeding from such tumors into the abdominal cavity of a threat to life. Contact pursued HRT has not been proved. Although such cases are extremely improbable, you should inform your doctor if you experience unusual sensations in the upper abdomen that do not disappear within a short time.
Reasons for immediate discontinuation of Angelica
You should immediately stop treatment and seek medical attention if you develop any of the following conditions:
- first caused migraine (typically characterized by throbbing headache and nausea preceded by visual disturbances);
- worsening of existing migraine; any unusually frequent or unusually severe headaches;
- sudden blurred vision or hearing;
- inflammation of the veins (phlebitis).
If the intake of the drug Angeliq ® you have a thrombosis or there is a suspicion that this could happen, you should immediately stop taking the drug and consult a doctor. By the warning signs of a possible thrombosis include:
– coughing up blood;
– unusual pain in the hands or feet, or swelling;
– sudden shortness of breath;
– loss of consciousness.
The drug Angeliq ® also should be discontinued immediately in the event of pregnancy or jaundice.
If you happened bleeding after a long period of amenorrhea, tell your doctor: this may require observation.
Bleeding from the vagina
Angeliq ® was developed for hormone replacement therapy without regular bleeding. However, during the first months of treatment, you may experience irregular bleeding from the vagina. As a rule, it is spotting, but sometimes there may be more intense and breakthrough bleeding. This bleeding usually are temporary and usually disappear with continued therapy.
If bleeding is stored for a long time, are amplified and, if after their prolonged absence (amenorrhea) you start bleeding, be sure to consult a doctor, because in this case it may be necessary corresponding inspection. schneller muskelaufbau anabolika ephedrin hcl anabolika f?r frauen