Category Archives: Steroids

anadrol steroid

Pharmacological properties anadrol steroid is an opioid receptor specific antagonist. Competitive binds to the opioid receptors of all types and prevents or eliminates the effect of both endogenous opioids and exogenous opioids – narcotic analgesics and their surrogates. The introduction of increased doses of opioids can reduce or eliminate the effect of this antagonist.

Pharmacodynamics . anadrol steroid does not have significant pharmacological properties of its own, except for a constriction of the pupil. At a dose of 50 mg anadrol steroid in 24 hours blocks the pharmacological effects caused by the intravenous administration of 25 mg of heroin. By doubling the dose of anadrol steroid its action is prolonged to 48 hours, while tripling – up to 72 hours.

The drug does not cause addiction and drug dependence.

Pharmacokinetics. anadrol steroid is well absorbed after oral administration, and 95% is metabolized in the liver with the formation of pharmacologically active metabolites. The major metabolite – 6-beta-anadrol steroid – also has properties competitive opioid antagonist. Also it is formed 2-hydroxy-3-methoxy-6-beta-anadrol steroid. The maximum concentration of anadrol steroid and 6-beta in plasma anadrol steroid is observed after 1 hour after dosing. The drug was well penetrates the blood-tissue barrier – distribution volume is 1350 liters. The half-life time in the blood plasma for anadrol steroid – 4 hours for its metabolite 6-beta-anadrol steroid – 13 hours, which explains its ability to cumulation. anadrol steroid and its metabolites undergo intrahepatic recycling. The drug is eliminated via the kidneys in unchanged form (approximately 1%) and in the form of metabolites (38% in free and bound form a 6-beta-anadrol steroid).

Indications
Complex therapy of opioid addiction (dependence) in order to maintain the patient condition in which opioids are not able to provide the characteristic action. The drug is prescribed only after relief of withdrawal symptoms. Application ANTAKSONA begin in specialized departments for addiction treatment 7-10 days after the last dose of the opioid drug. Later during outpatient treatment, the patient should be under medical supervision. The patient must be a positive setting for the treatment of drug addiction. Integrated alcoholism treatment, including the maintenance treatment, the same doses as in the background on the heroin addiction therapy.

Contraindications
The use of narcotic analgesics or positive analysis on the content in the urine of opioids. Positive test for the presence of opiates in urine. The opioid withdrawal syndrome. The lack of data on holding a provocative test with naloxone (see. Dosage and administration).

Hypersensitivity to the drug anadrol steroid history of patients. Acute hepatitis or liver failure. Do not set ANTAKSONA safety of patients younger than 18 years, during pregnancy and lactation.

Precautions: Violations of the liver and / or kidneys.

Dosing and Administration

Treatment for heroin addiction.

Phase introduction ANTAKSONOM therapy.
ANTAKSONOM Treatment may be started no earlier than 7-10 days after the last dose of the opioid drug, and in the absence of signs of withdrawal symptoms. Abstinence from drugs is determined by the results of a urine test for the maintenance of opioids. The treatment does not begin until before the provocative test with a 0.5 mg intravenous naloxone does not become negative. Naloxone trial is not conducted in patients with signs of abstinence syndrome or opioid detected in the urine. Re naloxone sample can be carried out after 24 hours. The first dose is usually ANTAKSONA 20 mg solution for oral administration. In the absence of an hour withdrawal symptoms the patient gave a residue (30 mg) daily doses. The doctor should monitor the act of swallowing of the drug solution.

Supportive therapy ANTAKSONOM.
After the run-in phase of 50 mg administered every 24 hours ANTAKSONA (this dose is sufficient to prevent the action of 25 mg IV administered heroin).

It is possible to use other treatment regimens:

  1. ANTAKSONA administered 50 mg daily for the first five days of the week and 100 mg on day 6;
  2. 100 mg ANTAKSONA administered every 2 days or 150 mg every three days;
  3. 100 mg administered on day 1 (eg. Monday), 100 mg of 2 day (eg. Tuesday) and 150 mg on day 5 (Friday). This scheme is suitable for patients with the installation of a long deprivation of opioids.

Minimum rate – from 3 months, the recommended rate – from 6 months.

Treatment of alcoholism.
The daily intake of 50 mg ANTAKSONA, the minimum rate – 3 months.

Side effects
in the therapeutic dose for patients whose body contains not opioids ANTAKSON usually does not cause serious side effects.

With a frequency of more than 10% as a pre-treatment ANTAKSONOM and against its use in patients observed: sleep disturbances, anxiety, irritability, abdominal pain, nausea and vomiting, weakness, headache, pain in muscles and joints. With a frequency of less than 10%: loss of appetite, constipation or diarrhea, agitation, dizziness, skin rash, feeling of fever, reduced sexual potency, slowing ejaculation.

In rare cases, marked fatigue, confusion, depression, hallucinations and nightmares, photophobia, cough. In the laboratory diagnosis may increase the activity of transaminases in blood lymphocytosis.

Since marked with signs with the same frequency as the met before treatment and during treatment with ANTAKSONA them, apparently, can not be regarded as manifestations of the side effects of the drug.

Describes one case of idiopathic thrombocytopenic purpura in a patient who may have been sensitized to ANTAKSONU during the previous treatment; recovery occurred after discontinuation of the drug, and a course of corticosteroid therapy.

Overdose
of sufficient clinical data on possible drug overdose no. For suspected intoxication should appoint symptomatic treatment.

The interaction with other drugs
Some preparations containing opioids (antitussives, antidiarrheals agents, narcotic analgesics) can not produce the desired effect in patients receiving ANTAKSON. In these cases, use of alternative formulations which do not contain the opioid. Hepatotoxic drugs increase the risk of liver damage. Cases of incompatibility with other drugs are described.

Cautions
Antakson must cancel at least 48 hours prior to surgery, which requires the appointment of opioid analgesics. The patient should have the card for information purposes ANTAKSONA other health workers in the event of need for emergency care. If you want to overcome the blocking of opioid receptors (general anesthesia, analgesia in emergency cases) to use higher doses of short-opioid analgesics to reduce the risk of respiratory depression and circulatory.

Effects on ability to drive vehicles and management mechanisms
In the recommended doses, the drug does not affect the work that requires quick reaction and management of vehicles tri tren

anadrol 50 for sale

Angeliq ® contains both types of hormone (estrogen and progestogen), the level of which is reduced during menopause. Thus, it replaces the hormones that are not produced in the body. Climacteric period is characterized by the symptoms caused by a gradual decrease in the ovaries produce hormones. In addition, some women reduction of these hormones can lead to a decrease in bone density (postmenopausal osteoporosis).

Contained in the product Angeliq ® estradiol prevents or relieves painful symptoms (menopausal complaints) such as “hot flashes”, sweating, sleep disturbances, depressive moods, increased nervous irritability, dizziness, headaches, and involuntary urination, dryness and burning sensation in vagina, pain during sexual intercourse. Adding a progestogen (drospirenone) prevents the development of endometrial hyperplasia and cancer.

In addition, clinical studies confirmed decrease in bowel cancer risk in postmenopausal women.

Angeliq ® prevents bone loss caused by estrogen deficiency (postmenopausal osteoporosis).

In addition, due to the antiandrogenic properties of drospirenone Angeliq ® has a therapeutic effect on androgen disorders, such as acne (acne), seborrhea (skin lesion with the dysfunction of the sebaceous glands), androgenic alopecia (hair loss due to high levels of androgens).

Drospirenone also has anti-mineralocorticoid activity, increases the excretion of sodium and water, which can prevent high blood pressure, weight gain, edema, breast tenderness and other symptoms associated with fluid retention.

According to their biochemical and pharmacological profile of drospirenone similar to the natural progesterone produced by a woman’s body.

Angeliq ® also has a positive effect on blood lipid profile (for example, reduces the level of total blood cholesterol).

Indications

 

  • Hormone replacement therapy (HRT) for menopausal disorders in postmenopausal women.
  • Prevention of postmenopausal osteoporosis.

 

Contraindications

HRT is not recommended to start if any of the conditions listed below. If any of these conditions arise during HRT, you should immediately stop using the product.

 

  • Pregnancy and lactation
  • Bleeding from the vagina of unknown origin
  • Confirmed or presumptive diagnosis of breast cancer
  • Confirmed or presumptive diagnosis of hormone-dependent precancerous disease or hormone-dependent cancer
  • Liver tumors present or in history (benign or malignant)
  • Severe liver disease
  • Severe kidney disease at present or in history (up to normalization of renal function)
  • Acute arterial thrombosis or thromboembolism, including those leading to myocardial infarction, stroke
  • Deep vein thrombosis in the acute stage, venous thromboembolism present or in history
  • Severe hypertriglyceridemia
  • Hypersensitivity to the drug Angeliq ® .

 

If any of these conditions occur in patients receiving Angelica, immediately discontinue use and consult your doctor

The use with caution

Angeliq ® should be used with caution in the following diseases: hypertension, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor), cholestatic jaundice or cholestatic pruritus during pregnancy, endometriosis, uterine fibroids, diabetes (see “Special Instructions”.) .

It should be appreciated that estrogens alone or in combination with progestins should be used with caution in the following diseases and conditions: smoking, hypercholesterolemia, obesity, systemic lupus erythematosus, dementia, gallbladder disease, thrombosis, retinal vessels, moderate hypertriglyceridemia, swelling in CHF, severe hypocalcemia, endometriosis, asthma, epilepsy, migraine, porphyria, liver hemangioma, hyperkalemia, a condition predisposing to the development of hyperkalemia, taking drugs that cause hyperkalemia – potassium-sparing diuretics, potassium drugs, ACE inhibitors, angiotensin II antagonists, and heparin receptors.

Pregnancy and lactation

HRT is contraindicated during pregnancy and lactation. . If pregnancy is detected during the reception of the drug Angelique, the drug should be immediately abolished.

Small amounts of sex hormones can be released from the mother’s milk.

Dosing and Administration

If you are taking estrogens or go to Angelique ® from another combined preparation for continuous reception, you can start treatment at any time. If you go to Angelique ® with a combined preparation for cyclical HRT should begin reception after the withdrawal bleeding.

Each package is designed for a 28-day reception.

Every day should take one anadrol 50 for sale coated. After receiving 28 anadrol 50 for sales from the current package, the next day, start a new pack Angeliq ® (continuous HRT), taking the first pill on the same day of the week as the first pill from the previous package.

The anadrol 50 for sale is swallowed whole with a little liquid. The time of day when you are taking a drug, it does not matter, but if you start to take the anadrol 50 for sales at any given time, you have to adhere to this time and beyond. Forgotten anadrol 50 for sale to drink as soon as possible. If it has been more than 24 hours after receiving the normal time, extra anadrol 50 for sale should be taken. When skipping a few pills may develop vaginal bleeding.

Side effect

During the first few months of therapy may be a breakthrough bleeding and spotting. The frequency of bleeding decreases with the duration of therapy .. It is a common symptom, which is detected in about one in five women is breast pain.

 

Systemic organ classes Often
(≥1 / 100 – <1/10)
Uncommon
(≥1 / 1000 and <1/100)
Rarely
(<1/1000)
Blood and lymphatic system Anemia
The immune system
Metabolism Changes in weight (increase or decrease), anorexia, appetite increase, hyperlipidemia
psychiatric disorders Depression, emotional lability, irritability Sleep disturbances, anxiety, decreased libido
Nervous system Headache Paresthesia, impaired ability to concentrate, dizziness vertigo
organ of vision eye diseases, visual disturbances
The organ of hearing Tinnitus
The cardiovascular system Palpitations, embolism, venous thrombosis, thrombophlebitis, arterial hypertension, migraine, varicose veins
Respiratory system Dyspnea
Liver, gastrointestinal tract Abdominal pain, nausea, abdominal enlargement Gastrointestinal disturbances, diarrhea, constipation, vomiting, dry mouth, flatulence, taste perversion, abnormal liver function tests indices cholelithiasis
Skin and subcutaneous tissue Diseases of the skin and hair, acne, alopecia, pruritus, rash, hirsutism
Musculoskeletal system, connective tissue Pain in extremity, back pain, arthralgia, muscle spasms myalgia
The kidneys and urinary system And urinary tract infections
Reproductive system, mammary gland Benign tumors of the breast, breast enlargement, increased uterine fibroids, benign tumors of the cervix, menstrual irregularities, discharge from the genital tract Breast cancer, endometrial hyperplasia, benign tumors of the uterus, fibrocystic disease of the breast, uterus, ovary, cervix, pelvic pain, vulvovaginal disorders, vaginal candidiasis, vaginitis, vaginal dryness salpingitis
General disorders and local Asthenia, local edema Generalized edema, chest pain, malaise, excessive sweating Chills

It reported the following adverse events in connection with taking HRT: nodosum or erythema multiforme, chloasma, purpura, pain and tension of the mammary glands, fatigue, intolerance to contact lenses.

If you think that on the background of Angelica you developed any side effects, even not included in this list, please send it to your doctor or pharmacist.

Overdose

There were no risk of serious side effects when taking the drug in a random amount exceeding many times the daily therapeutic dose. Symptoms that may occur with overdose include nausea, vomiting, bleeding from the vagina. No specific antidote, treatment – symptomatic. In case of overdose, contact your doctor.

Interaction with other drugs

Always tell your doctor assigns you Angeliq ® , which medicines you are taking. Inform your doctor assign you other drugs that you are taking Angeliq ® . If you have any doubts about any of you used the drug, consult your physician.

Before the start of HRT use should be discontinued use of hormonal contraceptives. If necessary, check with your doctor contraception what contraception you can use.

Some medicines may reduce the effectiveness of the drug Angeliq ® . These include drugs used to treat epilepsy (e.g., hydantoin, barbiturates, primidone, carbamazepine) and tuberculosis (eg, rifampicin), antibiotics for the treatment of other infectious diseases (e.g., penicillin and tetracycline). Angeliq ® has no negative effect on glucose tolerance.

 

  • Interaction with alcohol

 

Excessive consumption of alcohol at the time of hormone replacement therapy with Angeliq ® has an impact on the effectiveness of the drug.

special instructions

Medical examinations

Prior to receiving the drug, and then at regular intervals during treatment (at least 1 time per year) should be done gynecological examination, including examination of mammary glands, blood pressure and other necessary research.

If hormone replacement therapy is carried out at one of the diseases or conditions listed below, you may need close medical supervision. Therefore, if you have found one of these conditions, tell your doctor before taking Angeliq ® .

 

  • thrombosis

you or any of your close relatives in the present or in history. The risk increases with age and reaches a maximum when:
– you or your relatives from kto-libo kogda-libo already had thrombosis of legs or lungs
– you have varicose veins
– you have excess body weight
– risk of deep venous thrombosis is temporarily increased in result of the operation, serious injury, or prolonged immobility. If you use Angeliq ® , tell your doctor about any planned hospitalization or surgical intervention (for 4-6 weeks).

  • uterine fibroids;
  • endometriosis, now or in the past;
  • liver disease or gall bladder. After suffering a hepatitis use of the drug may not be earlier than 6 months (up to normalization of liver function);
  • jaundice during previous pregnancy or previous use of sex hormones;
  • diabetes;
  • hypertension (high blood pressure);
  • chloasma (yellowish-brown pigment spots on the skin) in the present or in the past. If they are, avoid prolonged exposure to the sun or ultraviolet radiation;
  • epilepsy;
  • benign breast disease (breast);
  • bronchial asthma;
  • migraine;
  • elevated blood triglyceride levels;
  • porphyria;
  • otosclerosis;
  • systemic lupus erythematosus;
  • chorea;

 

The following warnings related to the use of hormone replacement therapy should be considered when using the drug Angeliq ® .

Angeliq ® is not applicable for the purpose of contraception.

If necessary, the doctor will choose your contraception non-hormonal methods (with the exception of the calendar and temperature methods). If you suspect a pregnancy, you should stop taking the drug for as long as the pregnancy will not be excluded.

HRT and cancer

 

  • endometrial cancer

 

With prolonged use of estrogen alone, the probability of cancer uterine lining (endometrial cancer) increases. Progestogen used in the preparation Angeliq ® , prevents an increase in the risk.

Tell your doctor if the intake of Angeliq ® you are often violations of the cycle or breakthrough bleeding.

 

  • Mammary cancer.

 

According to the results of clinical trials and observational studies have found an increase in the relative risk of developing breast cancer in women who use HRT for several years. The relative risk increases with duration, but may be missing or reduced in the treatment of estrogen only. This increase is comparable to the increase in delaying the onset of natural menopause, the risk of breast cancer in women each year, as well as obesity and alcohol abuse. The increased risk gradually decreases to normal levels during the first few years after stopping HRT.

HRT increases mammographic breast density, which in some cases may adversely affect the radiological detection of breast cancer.

 

  • Swelling of the liver

 

In rare cases, the use of sex hormones observed the development of benign and even more rarely – malignant liver tumors. In some cases, bleeding from such tumors into the abdominal cavity of a threat to life. Contact pursued HRT has not been proved. Although such cases are extremely improbable, you should inform your doctor if you experience unusual sensations in the upper abdomen that do not disappear within a short time.

Reasons for immediate discontinuation of Angelica

You should immediately stop treatment and seek medical attention if you develop any of the following conditions:

 

  • first caused migraine (typically characterized by throbbing headache and nausea preceded by visual disturbances);
  • worsening of existing migraine; any unusually frequent or unusually severe headaches;
  • sudden blurred vision or hearing;
  • inflammation of the veins (phlebitis).

 

If the intake of the drug Angeliq ® you have a thrombosis or there is a suspicion that this could happen, you should immediately stop taking the drug and consult a doctor. By the warning signs of a possible thrombosis include:
– coughing up blood;
– unusual pain in the hands or feet, or swelling;
– sudden shortness of breath;
– loss of consciousness.

The drug Angeliq ® also should be discontinued immediately in the event of pregnancy or jaundice.

If you happened bleeding after a long period of amenorrhea, tell your doctor: this may require observation.

Bleeding from the vagina

Angeliq ® was developed for hormone replacement therapy without regular bleeding. However, during the first months of treatment, you may experience irregular bleeding from the vagina. As a rule, it is spotting, but sometimes there may be more intense and breakthrough bleeding. This bleeding usually are temporary and usually disappear with continued therapy.

If bleeding is stored for a long time, are amplified and, if after their prolonged absence (amenorrhea) you start bleeding, be sure to consult a doctor, because in this case it may be necessary corresponding inspection.

anadrol side effects

Flumazenil, a derivative imidazobenzodiazepinov – anadrol side effects antagonist. Specifically inhibits the effects of drugs acting on the CNS anadrol side effects receptors. Eliminates sedation, amnesia and psychomotor impairment caused by anadrol side effects receptor agonists. Somnolent and sedative effect of anadrol side effectss disappears within 1-2 minutes after i / v injection of flumazenil, but may gradually reappear in the next few hours, depending on the half-life and the dose of agonist and antagonist.

Flumazenil may have its own weak agonist (for example, anticonvulsant) activity.

In adult patients, which for several weeks received large doses of anadrol side effectss, flumazenil administration accompanied anadrol side effects withdrawal symptoms, including seizures.

 

Pharmacokinetics

 

Pharmacokinetics of flumazenil as a therapeutic as well as in the higher range of doses (100 mg) is dose-dependent.

Distribution

Flumazenil, a weak lipophilic base, approximately 50% bound to plasma proteins. Two thirds of the protein binding to albumin have to share. Flumazenil is extensively distributed in the extravascular space.Plasma concentrations of flumazenil decrease with a half-life 11.4 minutes during the distribution phase. when the distribution volume of the equilibrium concentration of 0.9-1.1 l / kg.

Metabolism

Flumazenil is extensively metabolized in the liver. The primary inactive metabolite in plasma (free form) and urine (free form and glucuronide) is a carboxylic acid. The main metabolite does not possess anadrol side effects agonist or antagonist activity on the results of pharmacological tests.

breeding

Summary clearance flumazenil is 0.8-1.0 l / h / kg, the liver is predominantly (99%) and depends on the size and hepatic blood flow. Excretion flumazenil almost complete after 72 hours, 90-95% is found in urine and 5.10% in the feces. Elimination is rapid, as shown by the short half-life equal to 40-80 minutes.

Eating during the intravenous infusion of flumazenil results in a 50% increase in clearance, most likely by increasing hepatic blood flow that accompanies a meal.

 

Pharmacokinetics in special clinical groups

In patients with impaired liver function half-life of flumazenil and longer total clearance lower than in healthy volunteers. The pharmacokinetics of flumazenil are not significantly changed in elderly and senile patients, regardless of gender, hemodialysis or renal failure.

In children older than 1 year half-life is more prone to fluctuations than in adults and amounts to an average of 40 minutes (range 20-75 minutes). Clearance and volume of distribution, correlated with body weight are in the same range as that of adults.

 

Indications for use:

 

 

Complete or partial removal of the central sedative effects of anadrol side effectss. The drug used in anesthesia and intensive care in the following indications.

Anesthesiology:

– Removal of inpatients from general anesthesia initiated and maintained with anadrol side effectss;

– The elimination of anadrol side effects sedation during short diagnostic and therapeutic procedures in inpatient and ambulatory patients.

Intensive care and management of patients with loss of consciousness of unknown etiology:

– Differential diagnosis with loss of consciousness of unknown etiology: setting or exclusion of the diagnosis of poisoning with anadrol side effectss;

– anadrol side effectss poisoning: the elimination of specific central effects of anadrol side effectss when they overdose (recovery of spontaneous breathing and consciousness, which eliminates the need for intubation and allows the patient extubated).

 

 Contraindications:

 

Hypersensitivity to the drug or any of its components.

Aneksat is contraindicated in patients receiving anadrol side effectss for the treatment of a condition is potentially life threatening (eg control of intracranial pressure or status epilepticus).

Cyclic antidepressant poisoning.

 

Pregnancy and breast-feeding

 

 

Although animal experiments at high doses of flumazenil are not mutagenic, embryotoxic, teratogenic and had no effect on fertility, the safety of its use in pregnant women has not been established.Therefore, his appointment should carefully weigh the benefits of application for mother and the possible risk to the fetus.

During the period of breast-feeding, parenteral administration of flumazenil in case of emergency is not contraindicated.

Dosage and administration:

 

The standard dosing regimen

Aneksat administered only intravenously (bolus or infusion) under the supervision of a qualified physician or anesthesiologist. The product is compatible with a 5% dextrose or 0.9% sodium chloride. To maintain sterility Aneksat should gain from the vial immediately before use. After a set of dilutions in the syringe or 5% dextrose or 0.9% sodium chloride, the drug must be used within 24 hours.

The dose should be titrated to achieve the desired effect. Since the duration of action of some anadrol side effectss may exceed that of flumazenil may require repeated administration of the drug, if sedation recurs after recovery of consciousness.

anesthesiology

The recommended initial dose of 0.2 mg / in 15 seconds. If after 60 seconds after the first intravenous dose of the desired recovery of consciousness does not occur, then you can enter a second dose (0.1 mg). If necessary, this procedure may be carried out at 60-second intervals until a total dose of – 1 mg. Generally, the dose is equal 0.3-0.6 mg, but individual requirement may vary considerably, depending on the dose and duration of the previously introduced features and anadrol side effects patient.

Intensive care and management of patients with loss of consciousness of unknown etiology

The recommended initial dose of 0.3 mg / in. If the desired level of recovery of consciousness occurs, flumazenil can be administered repeatedly, as described above, to a total dose of less than 2 mg.recommended drug intravenously administered repeatedly recurrence confusion when either bolus or as an intravenous infusion at a rate of 0.1-0.4 mg per hour. The rate of infusion selected individually to achieve the desired level of recovery of consciousness.

If, after repeated administration of flumazenil consciousness or respiratory function is restored is not enough, we must assume non-anadrol side effects etiology of impaired consciousness.

Patients in intensive care units, as well as in patients receiving long-term large doses of anadrol side effectss, individually selected dose of flumazenil under slow introduction should not cause withdrawal symptoms. When an undesirable symptoms hyperstimulation or intravenous diazepam midazolam, their carefully titrating dose depending on the patient response.

 

Special dosage instructions

Children older than 1 year

To eliminate conscious sedation caused by anadrol side effectss, the recommended starting dose of 0.01 mg / kg (0.2 mg) / in 15 seconds. If after another 45 seconds the desired level of recovery of consciousness occurs, it is possible to introduce another at 0.01 mg / kg (0.2 mg) with a 60-second intervals (but not more than 4 times) to a maximum total dose of 0.05 mg / kg, but not more than 1 mg.The dose is selected individually depending on the patient response.

Side effect:

 

Adults and children are well tolerated flumazenil. Adults even tolerate doses higher than recommended.

After rapid administration of flumazenil is rarely encountered anxiety, palpitations, feeling of fear. These unwanted effects usually do not require special treatment.

There are cases of seizures in patients with epilepsy or severe liver disease, especially after long-term treatment with anadrol side effectss or in the case of mixed drug overdose.

In the case of mixed drug overdose, especially cyclic antidepressants, may cause seizures and arrhythmias after eliminating the effects of anadrol side effectss.

In patients receiving long-term anadrol side effectss and stop taking them for a few weeks before the introduction Aneksata may develop withdrawal symptoms with the rapid introduction Anekcata.

Patients with a history of panic disorder in administration of flumazenil can trigger a panic attack.

Adverse reactions associated with the intake of flumazenil, occurring in 3-9% of cases: dizziness, headache, blurred vision, agitation, anxiety, nervousness, dry mouth, tremor, insomnia, ataxia (10%), shortness of breath, hyperventilation, palpitations, pain at the injection site, sweating.

From the gastrointestinal tract : nausea, vomiting (11%).

Adverse reactions associated with the reception of flumazenil, occurring in 1-3% of cases:

by the body as a whole : fatigue, local reactions (thrombophlebitis, rash);

on the part of the cardiovascular system : dilatation of the cutaneous vessels, a sense of “tide”;

the central nervous system : paresthesia (sensitivity infringement, hypoesthesia), emotional lability (crying, depersonalization, euphoria, dysphoria, depression, paranoia); with the senses : visual disturbances (diplopia, visual field defects).

Side effects occurring in less than 1% of cases, possibly related to the reception or withdrawal from anadrol side effectss flumazenil:

on the part of the nervous system : impaired concentration, delirium, convulsions, drowsiness;

From the senses : transient hearing loss, hyperacusis, tinnitus.

Overdose:

 

Data on acute overdose flumazenil limited. There is no specific antidote. In case of overdose, treatment should consist of general supportive measures, monitoring of vital signs and observation of the clinical status of the patient.

Even with intravenous doses higher than the recommended overdose symptoms were observed.

 

Interaction with other drugs

 

Flumazenil suppresses the central effects of anadrol side effectss by competitive inhibition at the receptor level. It also blocks the effects of non-anadrol side effects agonists (eg, zopiclone triazolpiridaziny et al.) To anadrol side effects receptors.

There were no pharmacokinetic interaction between flumazenil and anadrol side effects receptor agonists, ethanol.

Pharmacokinetics in the presence of anadrol side effects agonists flumazenil does not change, but changes and pharmacokinetics of flumazenil in the presence of anadrol side effects agonists. Pharmacokinetic interaction between ethanol and flumazenil absent.

 

special instructions

 

Caution should be exercised in the appointment of flumazenil in cases of mixed overdose of drugs because after elimination of anadrol side effects effects may occur toxic effects (eg, seizures and cardiac arrhythmias), other medications taken in excess doses (especially cyclic antidepressants).

Flumazenil is not recommended in patients with epilepsy who were treated with anadrol side effectss for a long time. Although flumazenil has its own weak anticonvulsant effect, a sharp decline in anadrol side effects effect in patients with epilepsy can cause seizures.

Patients who Aneksat was introduced to remove the effects of anadrol side effectss, should be observed for re-sedation, respiratory depression and other residual effects of anadrol side effectss for a certain time, considering the dose and duration of action of anadrol side effectss previously entered.

Aneksat not used to the full expiration of peripheral muscle relaxants, and the complete disappearance of neuromuscular blockade.

Flumazenil used with caution in patients with head injuries, because it can cause seizures or alter cerebral blood flow in patients receiving anadrol side effectss.

rapid introduction of flumazenil should be avoided in patients previously receiving long-term anadrol side effectss and completed treatment of within a few weeks prior to the appointment of flumazenil, as this may cause withdrawal symptoms, including agitation, anxiety, emotional lability as well as mild confusion and sensory violations.

Flumazenil is not recommended for the treatment of anadrol side effects dependence or for the relief of long-lasting symptoms of anadrol side effects withdrawal.

Flumazenil should be used with caution to remove the conscious sedation in children up to 1 year, for the treatment of overdose of anadrol side effectss in children during resuscitation in newborns and to eliminate the sedative effects of anadrol side effectss, which are used in the administration of anesthesia in children, because the experience of the drug in such situations is limited.

 

Effect on driving vehicles and working with machines and mechanisms

During the first 24 hours after administration of flumazenil should refrain from activities requiring increased attention (working with machines and mechanisms, driving vehicles) because it can renew the previously adopted or imposed anadrol side effectss.

 

Product form:

 

A solution for intravenous administration of 0.5 mg / 5 ml

5 ml of the product into vials made of glass of hydrolytic class 1 (EF) are hermetically sealed. On the vial has a blue dot; on the tip of the ampoule two rings – purple and green.

5 vials are placed in a cardboard tray with partitions, which, together with instructions for use placed in a cardboard box.

anadrol vs dbol

Endogenous androgens secreted by the testes (mainly anadrol vs dbol) and their main metabolite dihydroanadrol vs dbol are responsible for the development of the external and internal genital organs and for maintaining secondary sexual characteristics (stimulating hair growth, deepening of the voice, development of the libido); for the overall impact on protein anabolism; for the development of the skeletal muscles and the distribution of subcutaneous fat; for reducing urinary excretion of nitrogen, sodium, potassium, chloride, phosphate, and water. anadrol vs dbol does not cause testicular development: it reduces the pituitary secretion of gonadotropins.

Effects of anadrol vs dbol on some target organs occurs after peripheral conversion of anadrol vs dbol to estradiol, which then binds to the estrogen receptor in the nuclei of the cells of target organs (such as the pituitary, adipose tissue, brain, bone and testicular Leydig cells).

Pharmacokinetics

The degree of absorption of anadrol vs dbol through the skin ranges from about 9% to 14% of the applied dose.

After absorption of anadrol vs dbol through the skin into the systemic circulation flows in relatively constant concentrations for a 24-hour cycle.

anadrol vs dbol concentration in serum increases with the first hour after treatment, reaching a constant value from the second day of treatment. Daily fluctuations in anadrol vs dbol concentrations are of the same magnitude as observed in the circadian rhythms of change in the content of endogenous anadrol vs dbol. When an external route of administration thus avoiding possible blood distribution peaks arising during use of the injection process.

In contrast to oral androgen therapy, topical application of the drug did not cause an increase in liver steroid concentrations above physiological norms.

Application 5 g anadrol vs dbol anadrol vs dbol causes an average increase in the plasma concentration of approximately 2.5 ng / ml (8.7 nmol / L).

After the cessation of treatment for anadrol vs dbol concentrations begin to decline after about 24 hours after the last dose. Concentration returned to baseline levels after about 72-96 hours after the last dose.

The major active metabolites of anadrol vs dbol are dihydroanadrol vs dbol and estradiol.

anadrol vs dbol excreted primarily in the urine and the faeces as conjugated anadrol vs dbol metabolites.

Indications

Replacement therapy with anadrol vs dbol deficiency.

Contraindications

Androgens are contraindicated:

  • in the presence of carcinoma of the breast or prostate cancer or suspected their presence;
  • in case of hypersensitivity to anadrol vs dbol or other components of the preparation.

Experience with anadrol vs dbol in women and children is absent.

The drug should be used with caution if the patient has:

  • malignancies (because of the risk of hypercalcemia and hypercalciuria);
  • severe cardiac, hepatic or renal failure;
  • cardiac ischemia;
  • arterial hypertension;
  • epilepsy;
  • migraine.

Dosing and Administration

The recommended dose of 5 grams of gel (i.e. 50 mg of anadrol vs dbol) used 1 time per day at about the same time, preferably in the morning. Individual daily dose may be adjusted by the physician according to clinical and laboratory parameters in patients, but should not exceed 10 g of gel per day. Correction dosing regimen should be performed in steps of 2.5 g of gel per day.

The gel is applied to clean, dry, intact skin of the shoulders, upper arms and / or abdomen. After opening the bag must be immediately applied to the skin of all its contents and distribute a thin layer. You do not have to rub it into the skin. Let it dry for at least 3-5 minutes before dressing. After applying the gel, wash your hands with soap and water.

Do not apply the gel to the genital area, because the high content of ethanol in the formulation may cause local irritation.

Permanent anadrol vs dbol concentration in plasma is approximately on the second day of treatment anadrol vs dbol. For adjusting the dose of anadrol vs dbol necessary to determine the concentration of anadrol vs dbol in serum in the morning before application of the drug from the third day after treatment (within one week). The dosage can be reduced if the content of anadrol vs dbol in the plasma is increased. If low concentrations, the dose can be increased, but not more than 10 g of gel per day.

Side effects

In clinical trials, adverse effects anadrol vs dbol in the application of the recommended dose of 5 g of gel per day is most often seen in skin reactions: irritation at the application site, erythema, acne, dry skin.

In rare cases the following undesirable effects were observed:

  • general – changes the results of laboratory tests (polycythemia, decreased lipid levels), headache;
  • on the part of the genitourinary system: changes in the prostate gland, gynecomastia, mammalgia;
  • from the central and peripheral nervous system: dizziness, paraesthesia, amnesia, hyperaesthesia, mood changes;
  • with the cardiovascular system: elevation of blood pressure;
  • from the gastrointestinal tract: diarrhea;
  • of the skin and its appendages: alopecia.

In the appointment of high doses may develop the following clinical signs: irritability, nervousness, weight gain, prolonged or frequent erections. The emergence of such phenomena require dose adjustment.

Gynecomastia is common in patients undergoing treatment for hypogonadism. The preparation contains an alcohol, so when it is frequently applied to the skin may appear irritation and dryness.

Overdose

No cases of overdose when using anadrol vs dbol is not fixed.

Described only one case of overdose after anadrol vs dbol application, injectables. This patient had a stroke with a high concentration of anadrol vs dbol in the plasma 114 ng / ml (395 nmol / L). However, it is unlikely that such a plasma concentration of anadrol vs dbol may be achieved by applying to the skin the drug.

Interaction with other drugs

anadrol vs dbol should be used with caution with oral anticoagulants, as may increase the action of oral anticoagulants by modifying the hepatic synthesis of coagulation factors and competitive inhibition of plasma protein binding. It is recommended to monitor the prothrombin time. Patients receiving oral anticoagulants require frequent monitoring, particularly at the beginning and / or end of treatment with androgens.

Co-administration of anadrol vs dbol and ACTH or corticosteroids may increase the risk of edema. These drugs should also be administered with caution, especially in patients suffering from heart disease, kidney or liver.

Effects on laboratory tests: androgens may decrease levels of thyroxine-binding globulin, resulting in a decrease in serum concentrations of T4 and an increase in sensitivity to the T3 and T4. The levels of free thyroid hormones, however, remain unchanged, and thus there are no clinical manifestations of hypothyroidism.

special instructions

anadrol vs dbol should be used only when anadrol vs dbol deficiency accompanied by clinical manifestations such as regression of secondary sexual characteristics, change in body composition, asthenia, reduced libido, erectile dysfunction, etc. Before treatment, other possible causes of the above symptoms should be excluded.

Currently, no clear indicators of anadrol vs dbol for different age groups. However, it should be appreciated that physiologically serum anadrol vs dbol levels decline with age.

Because of the variability values of laboratory determination of anadrol vs dbol concentration should be in the same laboratory.

anadrol vs dbol is not used for the treatment of male infertility and erectile dysfunction, the cause of which is not associated with anadrol vs dbol deficiency.

Before prescribing anadrol vs dbol, all patients should be evaluated to rule out the possibility of the existence of prostate cancer, as androgens may accelerate the progression of sub-clinical prostatic cancer and benign prostatic hyperplasia. There should be a thorough and regular monitoring of the condition of the prostate (digital rectal examination, determination of prostate-specific antigen (PSA) in serum) and breast, at least once a year, every year, in elderly patients and patients at risk (with clinical or family factors) – twice a year.

anadrol vs dbol should be used with caution in patients with malignancies at risk of hypercalcaemia (and associated hypercalciuria), due to bone metastases. In these patients, it is recommended to control the concentration of calcium in serum.

Patients with severe cardiac, hepatic or renal insufficiency, treatment can cause complications anadrol vs dbol, characterized by edema with congestive heart failure or without it. In this case, treatment must be discontinued immediately. In addition, diuretic therapy may be required.

anadrol vs dbol should be used with caution in patients with coronary heart disease.

anadrol vs dbol may cause a rise in blood pressure, therefore anadrol vs dbol should be used with caution in patients with arterial hypertension.

Patients taking androgens for a long period, in addition to laboratory measurements of anadrol vs dbol concentration is necessary periodically to check the following laboratory parameters: hemoglobin, hematocrit (to detect polycythemia) and liver function tests.

anadrol vs dbol should be used with caution by patients with epilepsy and migraine as these conditions may be exacerbated.

data to increase the risk of sleep apnea in patients with hypogonadism have been published on treatment of anadrol vs dbol esters, especially in those who had risk factors such as obesity and chronic respiratory disease.

Patients receiving androgens increase insulin sensitivity may occur when a normal anadrol vs dbol concentration in the blood plasma.

Some clinical symptoms (irritability, nervousness, weight gain, prolonged or frequent erections) may indicate excessive androgen exposure requiring dosage adjustment.

If the patient develops a severe local reaction, the treatment should be reviewed and discontinued if necessary.

When using anadrol vs dbol athletes to take into account the fact that the preparation contains the active compound (anadrol vs dbol), which can produce positive reactions in anti-doping tests.

Potential anadrol vs dbol transfer
the appointment of anadrol vs dbol is necessary to inform the patient about the safety measures.

To guarantee partner safety, the patient needs, for example, advised to comply with the interval between anadrol vs dbol application and sexual intercourse, or to wear a T-shirt covering the application site of the gel, the contact period, or prinyaimat shower before sexual intercourse.

Preferably observe an interval of at least 6 hours between the time of applying the gel and taking a bath or shower. However, short showering the period from 1 to 6 hours after applying the gel has no significant effect on treatment.

The following precautions are recommended to take:

  • patient:
    • Wash hands with soap and water after applying the gel;
    • close the area of application of the gel clothing after it dries;
    • take a shower before any situation in which direct physical contact with another person is inevitable.
  • persons not taking anadrol vs dbol:
    • In case of contact with the area of application of the gel, not pre-washed with water, a rinse with water as soon as possible with soap and water area of the skin to which anadrol vs dbol could get.
    • inform your doctor about the emergence and development of such features giperandrogenizatsii as acne or changes in normal hair growth.

In the case of pregnant partners of a patient must be attentive to the observance of the precautionary measures. Pregnant women should avoid any contact with skin. In case of contact with the drug a woman as quickly wash the area of skin on which was a gel with water and soap.

In case of contact with children are recommended to wear clothing covering the application of the gel place to avoid the risk of skin contact with the drug children.

anadrol vs dbol should not be administered to patients who can not comply with safety instructions (eg, suffering from severe chronic alcoholism, substance abuse, severe psychiatric disorders).

Effects on ability to drive a car and other mechanisms

anadrol vs dbol® not affect the ability to drive a car and the management of machines and mechanisms.

release Form

Gel for topical application of 1%: 2.5 or 5.0 g of gel in polyethylene disposable bags and of laminated aluminum foil. At 10 or 30 bags in a carton box together with instructions for use. buy anabolic steroids online bruce lee’s workout anabolic steroids online uk

anadrol results

Treatment anadrol results TC hypogonadal men dose-dependently restores to normal total testosterone levels in serum and levels of bioavailable testosterone treatment increases the content of dihydrotestosterone (DHT) and estradiol (E2) serum content decrease globulin sex hormone binding (SHBG ), luteinizing hormone (LH) and follicle stimulating hormone (FSH). As boys and adult men with ptogonadizmom treatment TK anadrol results leads to a decrease in the symptoms of testosterone deficiency. Moreover, treatment increases bone mineral density and lean body mass (body mass by reducing fat). Treatment improves sexual function, including libido and potency.
The treatment dose dependently decreases the content of high density lipoprotein (HDL), low density lipoprotein (LDL) and triglycerides, increases levels of hemoglobin and hematocrit, as well clinically insignificant change in the content of liver enzymes, and prostate specific antigen . Treatment may lead to an increase in prostate size, but the side effects of prostate were observed. In patients with hypogonadism and diabetes, there was an increase in insulin sensitivity and a decrease in blood glucose levels.
The boys with delayed growth and puberty, treatment with anadrol results TC initially accelerate the growth and development of secondary sexual characteristics.
In women, ovariectomized with treating only estrogen adding anadrol results TC increases libido, increased bone mineral density and reduced body fat mass. At transgender (of women in men) treatment increases the TK anadrol results masculinization.

Pharmacokinetics Absorption After oral administration of testosterone undecanoate significant part together with a lipophilic solvent absorbed in the small intestine and into the lymph system, thus partially bypassing initial passage through the liver. TK anadrol results ® should be taken with food to improve absorption. Bioavailability is about 7%. Distribution Of lymphatic system undecanoate testosterone and hydrolysed to testosterone. A single dose of 80 to 160 mg anadrol results TC ® results in a clinically significant increase in the total testosterone concentration in plasma, with a maximum concentration of about 40 nmol / l (Cmax) achieved after about 4-5 hours (t max ) after administration. Increased testosterone concentration in the blood plasma remains for at least 8 hours. Testosterone and testosterone undecanoate display a high level (over 97%) of non-specific protein binding kroviiGSPG. Metabolism In plasma and tissues testosterone undecanoate is hydrolyzed to the natural male androgen -testosterone.Testosterone is further metabolized to dihydrotestosterone and estradiol. Elimination Testosterone, estradiol and dihydrotestosterone are metabolized by conventional means. Elimination occurs mainly via the urine as conjugates (etioholanolon and androsterone). Linearity The linearity of dosing has been demonstrated for doses of 40 to 240 mg / day.

Indications

Testosterone replacement therapy in males for conditions associated with primary and secondary hypogonadism, both congenital and acquired.

Contraindications

 

  • Having now or history of prostate or breast cancer;
  • Hypersensitivity to any components of the preparation.
    If you have one of these diseases, before taking this medication, you should consult with your doctor.The caution
    in patients with previous heart disease, kidney or liver disease treated with androgens may cause complications characterized by edema with or without congestive heart failure.
    There is no exact data and recommendations on the safety of treatment with testosterone esters men sleep apnea. Needed weighted clinical judgment and caution in patients with the presence of risk factors such as obesity or chronic lung disease.
    When the side effects associated with treatment with androgens, taking anadrol results TC ® should stop or reduce the dose.
    If you have one of these diseases, before taking the drug should consult a doctor.Dosing and Administration
    Dose picked individually, depending on the clinical effect.
    Admission for adults:
    In general, the initial dose is 120-160 mg daily for 2-3 weeks. The maintenance dose of 40-120 mg per day, its choice should be based on the clinical effects obtained in the first weeks of therapy. To improve the absorption of the drug should be taken during meals with a little water. The capsules should be swallowed whole without chewing. It is advisable to take the first half of the dose in the morning and half in the evening. If it is an odd number of capsules, the higher the dose should be taken in the morning.

    Side effects
    The following adverse reactions have been associated with androgen therapy:

     

    Class system / organ MedDRA term
    Neoplasms benign, malignant and unspecified (including cysts and polyps) Prostate cancer (progression of subclinical prostate cancer)
    Disorders of the circulatory and lymphatic systems polycythemia
    Disorders of metabolism and nutrition fluid retention
    Psychiatric disorders Depression, nervousness, mood disturbances, libido increased, libido decrease
    Violations of the musculoskeletal – and connective tissue myalgia
    Vascular disorders hypertension
    Gastrointestinal disorders Nausea
    Violations of the skin and subcutaneous tissue The itch, acne
    Violations of the reproductive system and breast Gynecomastia, oligospermia, priapism, increased prostate size
    research Abnormal hepatic studies lipids (decrease in HDL, LDL, triglycerides in plasma), the increase in the concentration of prostate specific antigen

    Some patients may experience diarrhea, and pain or discomfort in the stomach area while taking anadrol results TC.
    If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, inform your doctor.

    Overdose
    . The acute toxicity of testosterone have not expressed
    Overdose TK anadrol results may cause gastro-intestinal disturbances in connection with the content of castor oil.
    Treatment: gastric lavage, symptomatic treatment.

    Interaction with other drugs
    Inductors microsomal oxidation enzymes may decrease and enzyme inhibitors of microsomal oxidation may increase testosterone levels. Hence, while the reception, the dose should be adjusted anadrol results TC.
    Androgens can increase glucose tolerance and reduce the need for insulin or other antidiabetic drugs. Androgens may enhance the anticoagulant effect of coumarin-type, which allows to reduce the dose of these funds.

    Specific guidance
    should be monitored following parameters in people taking anadrol results LC ® (the first year of admission – quarterly, then once a year):

  • digital rectal prostate study and the level of prostate specific antigen;
  • hematocrit and hemoglobin levels to exclude polycythemia.
    The boys at prepubertal should monitor the increase in growth and sexual development, as TK anadrol results ® in high dosages may accelerate epiphyseal closure and sexual maturation.Composition
    Capsules 40 mg.
    10 capsules in blister PVC / A1. 1 blister in a hermetically sealed sachet made of laminated aluminum foil. At 3, 6 or 12 is placed in a sachet pack carton along with instructions for use.

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