Endogenous androgens secreted by the testes (mainly anadrol vs dbol) and their main metabolite dihydroanadrol vs dbol are responsible for the development of the external and internal genital organs and for maintaining secondary sexual characteristics (stimulating hair growth, deepening of the voice, development of the libido); for the overall impact on protein anabolism; for the development of the skeletal muscles and the distribution of subcutaneous fat; for reducing urinary excretion of nitrogen, sodium, potassium, chloride, phosphate, and water. anadrol vs dbol does not cause testicular development: it reduces the pituitary secretion of gonadotropins.
Effects of anadrol vs dbol on some target organs occurs after peripheral conversion of anadrol vs dbol to estradiol, which then binds to the estrogen receptor in the nuclei of the cells of target organs (such as the pituitary, adipose tissue, brain, bone and testicular Leydig cells).
The degree of absorption of anadrol vs dbol through the skin ranges from about 9% to 14% of the applied dose.
After absorption of anadrol vs dbol through the skin into the systemic circulation flows in relatively constant concentrations for a 24-hour cycle.
anadrol vs dbol concentration in serum increases with the first hour after treatment, reaching a constant value from the second day of treatment. Daily fluctuations in anadrol vs dbol concentrations are of the same magnitude as observed in the circadian rhythms of change in the content of endogenous anadrol vs dbol. When an external route of administration thus avoiding possible blood distribution peaks arising during use of the injection process.
In contrast to oral androgen therapy, topical application of the drug did not cause an increase in liver steroid concentrations above physiological norms.
Application 5 g anadrol vs dbol anadrol vs dbol causes an average increase in the plasma concentration of approximately 2.5 ng / ml (8.7 nmol / L).
After the cessation of treatment for anadrol vs dbol concentrations begin to decline after about 24 hours after the last dose. Concentration returned to baseline levels after about 72-96 hours after the last dose.
The major active metabolites of anadrol vs dbol are dihydroanadrol vs dbol and estradiol.
anadrol vs dbol excreted primarily in the urine and the faeces as conjugated anadrol vs dbol metabolites.
Replacement therapy with anadrol vs dbol deficiency.
Androgens are contraindicated:
- in the presence of carcinoma of the breast or prostate cancer or suspected their presence;
- in case of hypersensitivity to anadrol vs dbol or other components of the preparation.
Experience with anadrol vs dbol in women and children is absent.
The drug should be used with caution if the patient has:
- malignancies (because of the risk of hypercalcemia and hypercalciuria);
- severe cardiac, hepatic or renal failure;
- cardiac ischemia;
- arterial hypertension;
Dosing and Administration
The recommended dose of 5 grams of gel (i.e. 50 mg of anadrol vs dbol) used 1 time per day at about the same time, preferably in the morning. Individual daily dose may be adjusted by the physician according to clinical and laboratory parameters in patients, but should not exceed 10 g of gel per day. Correction dosing regimen should be performed in steps of 2.5 g of gel per day.
The gel is applied to clean, dry, intact skin of the shoulders, upper arms and / or abdomen. After opening the bag must be immediately applied to the skin of all its contents and distribute a thin layer. You do not have to rub it into the skin. Let it dry for at least 3-5 minutes before dressing. After applying the gel, wash your hands with soap and water.
Do not apply the gel to the genital area, because the high content of ethanol in the formulation may cause local irritation.
Permanent anadrol vs dbol concentration in plasma is approximately on the second day of treatment anadrol vs dbol. For adjusting the dose of anadrol vs dbol necessary to determine the concentration of anadrol vs dbol in serum in the morning before application of the drug from the third day after treatment (within one week). The dosage can be reduced if the content of anadrol vs dbol in the plasma is increased. If low concentrations, the dose can be increased, but not more than 10 g of gel per day.
In clinical trials, adverse effects anadrol vs dbol in the application of the recommended dose of 5 g of gel per day is most often seen in skin reactions: irritation at the application site, erythema, acne, dry skin.
In rare cases the following undesirable effects were observed:
- general – changes the results of laboratory tests (polycythemia, decreased lipid levels), headache;
- on the part of the genitourinary system: changes in the prostate gland, gynecomastia, mammalgia;
- from the central and peripheral nervous system: dizziness, paraesthesia, amnesia, hyperaesthesia, mood changes;
- with the cardiovascular system: elevation of blood pressure;
- from the gastrointestinal tract: diarrhea;
- of the skin and its appendages: alopecia.
In the appointment of high doses may develop the following clinical signs: irritability, nervousness, weight gain, prolonged or frequent erections. The emergence of such phenomena require dose adjustment.
Gynecomastia is common in patients undergoing treatment for hypogonadism. The preparation contains an alcohol, so when it is frequently applied to the skin may appear irritation and dryness.
No cases of overdose when using anadrol vs dbol is not fixed.
Described only one case of overdose after anadrol vs dbol application, injectables. This patient had a stroke with a high concentration of anadrol vs dbol in the plasma 114 ng / ml (395 nmol / L). However, it is unlikely that such a plasma concentration of anadrol vs dbol may be achieved by applying to the skin the drug.
Interaction with other drugs
anadrol vs dbol should be used with caution with oral anticoagulants, as may increase the action of oral anticoagulants by modifying the hepatic synthesis of coagulation factors and competitive inhibition of plasma protein binding. It is recommended to monitor the prothrombin time. Patients receiving oral anticoagulants require frequent monitoring, particularly at the beginning and / or end of treatment with androgens.
Co-administration of anadrol vs dbol and ACTH or corticosteroids may increase the risk of edema. These drugs should also be administered with caution, especially in patients suffering from heart disease, kidney or liver.
Effects on laboratory tests: androgens may decrease levels of thyroxine-binding globulin, resulting in a decrease in serum concentrations of T4 and an increase in sensitivity to the T3 and T4. The levels of free thyroid hormones, however, remain unchanged, and thus there are no clinical manifestations of hypothyroidism.
anadrol vs dbol should be used only when anadrol vs dbol deficiency accompanied by clinical manifestations such as regression of secondary sexual characteristics, change in body composition, asthenia, reduced libido, erectile dysfunction, etc. Before treatment, other possible causes of the above symptoms should be excluded.
Currently, no clear indicators of anadrol vs dbol for different age groups. However, it should be appreciated that physiologically serum anadrol vs dbol levels decline with age.
Because of the variability values of laboratory determination of anadrol vs dbol concentration should be in the same laboratory.
anadrol vs dbol is not used for the treatment of male infertility and erectile dysfunction, the cause of which is not associated with anadrol vs dbol deficiency.
Before prescribing anadrol vs dbol, all patients should be evaluated to rule out the possibility of the existence of prostate cancer, as androgens may accelerate the progression of sub-clinical prostatic cancer and benign prostatic hyperplasia. There should be a thorough and regular monitoring of the condition of the prostate (digital rectal examination, determination of prostate-specific antigen (PSA) in serum) and breast, at least once a year, every year, in elderly patients and patients at risk (with clinical or family factors) – twice a year.
anadrol vs dbol should be used with caution in patients with malignancies at risk of hypercalcaemia (and associated hypercalciuria), due to bone metastases. In these patients, it is recommended to control the concentration of calcium in serum.
Patients with severe cardiac, hepatic or renal insufficiency, treatment can cause complications anadrol vs dbol, characterized by edema with congestive heart failure or without it. In this case, treatment must be discontinued immediately. In addition, diuretic therapy may be required.
anadrol vs dbol should be used with caution in patients with coronary heart disease.
anadrol vs dbol may cause a rise in blood pressure, therefore anadrol vs dbol should be used with caution in patients with arterial hypertension.
Patients taking androgens for a long period, in addition to laboratory measurements of anadrol vs dbol concentration is necessary periodically to check the following laboratory parameters: hemoglobin, hematocrit (to detect polycythemia) and liver function tests.
anadrol vs dbol should be used with caution by patients with epilepsy and migraine as these conditions may be exacerbated.
data to increase the risk of sleep apnea in patients with hypogonadism have been published on treatment of anadrol vs dbol esters, especially in those who had risk factors such as obesity and chronic respiratory disease.
Patients receiving androgens increase insulin sensitivity may occur when a normal anadrol vs dbol concentration in the blood plasma.
Some clinical symptoms (irritability, nervousness, weight gain, prolonged or frequent erections) may indicate excessive androgen exposure requiring dosage adjustment.
If the patient develops a severe local reaction, the treatment should be reviewed and discontinued if necessary.
When using anadrol vs dbol athletes to take into account the fact that the preparation contains the active compound (anadrol vs dbol), which can produce positive reactions in anti-doping tests.
Potential anadrol vs dbol transfer
the appointment of anadrol vs dbol is necessary to inform the patient about the safety measures.
To guarantee partner safety, the patient needs, for example, advised to comply with the interval between anadrol vs dbol application and sexual intercourse, or to wear a T-shirt covering the application site of the gel, the contact period, or prinyaimat shower before sexual intercourse.
Preferably observe an interval of at least 6 hours between the time of applying the gel and taking a bath or shower. However, short showering the period from 1 to 6 hours after applying the gel has no significant effect on treatment.
The following precautions are recommended to take:
- Wash hands with soap and water after applying the gel;
- close the area of application of the gel clothing after it dries;
- take a shower before any situation in which direct physical contact with another person is inevitable.
- persons not taking anadrol vs dbol:
- In case of contact with the area of application of the gel, not pre-washed with water, a rinse with water as soon as possible with soap and water area of the skin to which anadrol vs dbol could get.
- inform your doctor about the emergence and development of such features giperandrogenizatsii as acne or changes in normal hair growth.
In the case of pregnant partners of a patient must be attentive to the observance of the precautionary measures. Pregnant women should avoid any contact with skin. In case of contact with the drug a woman as quickly wash the area of skin on which was a gel with water and soap.
In case of contact with children are recommended to wear clothing covering the application of the gel place to avoid the risk of skin contact with the drug children.
anadrol vs dbol should not be administered to patients who can not comply with safety instructions (eg, suffering from severe chronic alcoholism, substance abuse, severe psychiatric disorders).
Effects on ability to drive a car and other mechanisms
anadrol vs dbol® not affect the ability to drive a car and the management of machines and mechanisms.
Gel for topical application of 1%: 2.5 or 5.0 g of gel in polyethylene disposable bags and of laminated aluminum foil. At 10 or 30 bags in a carton box together with instructions for use.