Pharmacological properties anadrol steroid is an opioid receptor specific antagonist. Competitive binds to the opioid receptors of all types and prevents or eliminates the effect of both endogenous opioids and exogenous opioids – narcotic analgesics and their surrogates. The introduction of increased doses of opioids can reduce or eliminate the effect of this antagonist.
Pharmacodynamics . anadrol steroid does not have significant pharmacological properties of its own, except for a constriction of the pupil. At a dose of 50 mg anadrol steroid in 24 hours blocks the pharmacological effects caused by the intravenous administration of 25 mg of heroin. By doubling the dose of anadrol steroid its action is prolonged to 48 hours, while tripling – up to 72 hours.
The drug does not cause addiction and drug dependence.
Pharmacokinetics. anadrol steroid is well absorbed after oral administration, and 95% is metabolized in the liver with the formation of pharmacologically active metabolites. The major metabolite – 6-beta-anadrol steroid – also has properties competitive opioid antagonist. Also it is formed 2-hydroxy-3-methoxy-6-beta-anadrol steroid. The maximum concentration of anadrol steroid and 6-beta in plasma anadrol steroid is observed after 1 hour after dosing. The drug was well penetrates the blood-tissue barrier – distribution volume is 1350 liters. The half-life time in the blood plasma for anadrol steroid – 4 hours for its metabolite 6-beta-anadrol steroid – 13 hours, which explains its ability to cumulation. anadrol steroid and its metabolites undergo intrahepatic recycling. The drug is eliminated via the kidneys in unchanged form (approximately 1%) and in the form of metabolites (38% in free and bound form a 6-beta-anadrol steroid).
Complex therapy of opioid addiction (dependence) in order to maintain the patient condition in which opioids are not able to provide the characteristic action. The drug is prescribed only after relief of withdrawal symptoms. Application ANTAKSONA begin in specialized departments for addiction treatment 7-10 days after the last dose of the opioid drug. Later during outpatient treatment, the patient should be under medical supervision. The patient must be a positive setting for the treatment of drug addiction. Integrated alcoholism treatment, including the maintenance treatment, the same doses as in the background on the heroin addiction therapy.
The use of narcotic analgesics or positive analysis on the content in the urine of opioids. Positive test for the presence of opiates in urine. The opioid withdrawal syndrome. The lack of data on holding a provocative test with naloxone (see. Dosage and administration).
Hypersensitivity to the drug anadrol steroid history of patients. Acute hepatitis or liver failure. Do not set ANTAKSONA safety of patients younger than 18 years, during pregnancy and lactation.
Precautions: Violations of the liver and / or kidneys.
Dosing and Administration
Treatment for heroin addiction.
Phase introduction ANTAKSONOM therapy.
ANTAKSONOM Treatment may be started no earlier than 7-10 days after the last dose of the opioid drug, and in the absence of signs of withdrawal symptoms. Abstinence from drugs is determined by the results of a urine test for the maintenance of opioids. The treatment does not begin until before the provocative test with a 0.5 mg intravenous naloxone does not become negative. Naloxone trial is not conducted in patients with signs of abstinence syndrome or opioid detected in the urine. Re naloxone sample can be carried out after 24 hours. The first dose is usually ANTAKSONA 20 mg solution for oral administration. In the absence of an hour withdrawal symptoms the patient gave a residue (30 mg) daily doses. The doctor should monitor the act of swallowing of the drug solution.
Supportive therapy ANTAKSONOM.
After the run-in phase of 50 mg administered every 24 hours ANTAKSONA (this dose is sufficient to prevent the action of 25 mg IV administered heroin).
It is possible to use other treatment regimens:
- ANTAKSONA administered 50 mg daily for the first five days of the week and 100 mg on day 6;
- 100 mg ANTAKSONA administered every 2 days or 150 mg every three days;
- 100 mg administered on day 1 (eg. Monday), 100 mg of 2 day (eg. Tuesday) and 150 mg on day 5 (Friday). This scheme is suitable for patients with the installation of a long deprivation of opioids.
Minimum rate – from 3 months, the recommended rate – from 6 months.
Treatment of alcoholism.
The daily intake of 50 mg ANTAKSONA, the minimum rate – 3 months.
in the therapeutic dose for patients whose body contains not opioids ANTAKSON usually does not cause serious side effects.
With a frequency of more than 10% as a pre-treatment ANTAKSONOM and against its use in patients observed: sleep disturbances, anxiety, irritability, abdominal pain, nausea and vomiting, weakness, headache, pain in muscles and joints. With a frequency of less than 10%: loss of appetite, constipation or diarrhea, agitation, dizziness, skin rash, feeling of fever, reduced sexual potency, slowing ejaculation.
In rare cases, marked fatigue, confusion, depression, hallucinations and nightmares, photophobia, cough. In the laboratory diagnosis may increase the activity of transaminases in blood lymphocytosis.
Since marked with signs with the same frequency as the met before treatment and during treatment with ANTAKSONA them, apparently, can not be regarded as manifestations of the side effects of the drug.
Describes one case of idiopathic thrombocytopenic purpura in a patient who may have been sensitized to ANTAKSONU during the previous treatment; recovery occurred after discontinuation of the drug, and a course of corticosteroid therapy.
of sufficient clinical data on possible drug overdose no. For suspected intoxication should appoint symptomatic treatment.
The interaction with other drugs
Some preparations containing opioids (antitussives, antidiarrheals agents, narcotic analgesics) can not produce the desired effect in patients receiving ANTAKSON. In these cases, use of alternative formulations which do not contain the opioid. Hepatotoxic drugs increase the risk of liver damage. Cases of incompatibility with other drugs are described.
Antakson must cancel at least 48 hours prior to surgery, which requires the appointment of opioid analgesics. The patient should have the card for information purposes ANTAKSONA other health workers in the event of need for emergency care. If you want to overcome the blocking of opioid receptors (general anesthesia, analgesia in emergency cases) to use higher doses of short-opioid analgesics to reduce the risk of respiratory depression and circulatory.
Effects on ability to drive vehicles and management mechanisms
In the recommended doses, the drug does not affect the work that requires quick reaction and management of vehicles tri tren