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Combined preparation. Paracetamol has analgesic, antipyretic and anti-inflammatory effect of weakly expressed. Phenylephrine hydrochloride – alpha-agonists has a vasoconstrictor effect, reduces edema and hyperemia of the mucous membranes of the nose and paranasal sinuses. Chlorpheniramine anadrol pills – blocker H 1 – histamine receptors – has anti-allergic effect, reduces the severity of local exudative manifestations eliminates watery eyes, itchy eyes and nose.

Indications for use.

Symptomatic treatment of “colds”, influenza, SARS (a feverish syndrome, pain, rhinorrhea).

Contraindications.

Hypersensitivity to the individual components of the preparation. Pregnancy, lactation. Portal giiertenziya, alcoholism, renal failure, deficiency of glucose-6-phosphate dehydrogenase. Do not use in children under 12 years.

With care
to apply at: hypertension, severe cardiovascular diseases, diabetes, asthma, chronic obstructive pulmonary disease, hyperthyroidism, pheochromocytoma, angle-closure glaucoma, severe anadrol pills liver or kidney problems, difficulty urinating in prostate cancer, blood diseases, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rothera).

Dosage and administration.

Inside. Adults and children over 12 years: 1 sachet every 4 hours, but not more than 4 bags per day. Before receiving content 1 sachet must dissolve in a beaker of hot water.

Duration of treatment is not more than 3 days. In the absence of a sufficient therapeutic effect, the presence of high temperature, which is held against the background of more than 3 days of treatment, as well as the appearance of new symptoms – seek immediate medical attention.

Side effects.

Allergic reactions (rash, pruritus, urticaria, angionevroticheeky edema), increased excitability (especially in children), sleep disturbance, drowsiness, decreased speed of psychomotor reactions, fatigue, nausea, vomiting, stomach pain, palpitations, increased blood pressure, dizziness, , mydriasis, paresis of accommodation, increased intraocular pressure, dry mouth, urinary retention.
Given the presence of paracetamol: seldom – disorders of the hematopoietic system (anemia, thrombocytopenia, leukopenia, agranulocytosis); chronic administration of high doses – may be hepatotoxic and nephrotoxic effects, hemolytic anemia, methemoglobinemia, pancytopenia.

Overdose:

Tied usually paracetamol, appears after taking more than 10-15 g of the latter. There are: pale skin, anorexia, nausea, vomiting, epigastric pain, increased activity of “liver” transaminases, increased prothrombin time, hepatotoxic and nephrotoxic effects, in severe cases, develops liver failure, encephalopathy and coma.

Treatment: gastric lavage, activated carbon in the first 6 hours, the introduction of SH-groups donators and precursors of glutathione synthesis – methionine after 8-9 hours after the overdose and N-acetyl cysteine after 12 hours.

Interaction with other drugs. It is recommended to refrain from taking the drug while taking monoamnooksidazy inhibitors. The risk of hepatotoxic action of paracetamol is increased with concomitant administration anadrol pills of barbiturates, diphenylhydantoin, carbamazepine, rifampicin, zidovudine, and other inducers of microsomal liver enzymes. It enhances the effect of sedatives, ethanol. Ethanol enhances the sedative effect of chlorpheniramine. Antidepressants, antipsychotics and antiparkinsonian, fenotiazinovys derivatives increase the risk of urinary retention, dry mouth, constipation.

Special instructions.

During the period of treatment should refrain from drinking alcohol, hypnotics and anxiolytics (tranquilizers) medications; avoid driving vehicles, using machinery, and other potentially dangerous activities. Do not take with other medicines containing paracetamol. If symptoms persist for 3-5 days, consult a doctor.

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Antithrombin III – virusinaktivirovanny antithrombin III concentrate.
Antithrombin III is a naturally occurring inhibitor of blood coagulation, acting primarily by inhibiting thrombin and activated Factor X. When combined with heparin inhibitory effect of antithrombin III is enhanced.

Indications
Application Antithrombin III shown activity in patients with antithrombin III in plasma less than 70% (congenital and acquired antithrombin deficiency) for the prevention of thrombotic and thromboembolic complications.
Also, the use of antithrombin III is shown in the following cases:

  • surgery, pregnancy and childbirth in patients with congenital antithrombin III deficiency
  • lack of or insignificant clinical effect in the treatment of heparin
  • the presence or risk of disseminated intravascular coagulation (for example, associated trauma, septic complications, shock, preeclampsia and other disorders caused by acute consumption coagulopathy)
  • the presence or risk of thrombosis in patients with nephrotic syndrome or inflammatory diseases of the bladder
  • surgery or bleeding in patients with severe liver failure, especially in patients receiving clotting factor concentrates.

Contraindications:
Not identified. Hypersensitivity to the drug.

Cautions
In the production of products that are made from human blood, it is impossible to completely eliminate the risk of diseases caused by the transfer of infectious agents, including those of unknown origin, with the introduction of the drug. Therefore, donors are selected according to strict criteria, carried out the study and selection of plasma taken, as well as laboratory testing of plasma pools (plasma Security Program). The production process of antithrombin III includes special treatment methods aimed at removing and inactivating viruses (a ten heating the solution at 60 ° C).
For production of Antithrombin III is used plasma only healthy donors examination which for antibodies to HIV-1, HIV-2, hepatitis C (HCV), as well as the surface antigen of hepatitis B virus (HbsAg) gave negative results. The level of hepatic transaminases (ALT) donors do not exceed the allowable values. Samples of plasma pool in addition to conventional methods well researched for HIV antibodies, HCV and HbsAg. Further research conducted on the viral genome of HIV, HBV, HCV polymerase chain reaction (PCR). PCR is a highly sensitive method which, unlike the study for the presence of antibodies capable of detecting the virus genome itself. The production process is prohibited, except those of the plasma samples in which PCR analysis did not reveal viral genomes.
In addition, according to the Security Plasma Program carried out quarantine of each plasma dose and retrospective analysis that provides complete control over the withdrawal of donors.
Efficiency undertaken during the production of security measures has been demonstrated in studies with human immunodeficiency virus (HIV), hepatitis a virus and models of hepatitis viruses B and C (HBV, HCV), as well as non-enveloped virus.
Clinical studies conducted in accordance with the criteria of the International Society on thrombosis and haemostasis, as well as pharmaco-epidemiological observations antithrombin III showed no transmission of hepatitis virus preparation (HBV, HCV, or non-a non-B hepatitis) and HIV, while at the time of PCR product has not been tested. Prescribe drugs to pregnant women with caution, after careful assessment of the possible risks and benefits.

Dosage and administration
of antithrombin III Dosage depends on the etiology and severity of antithrombin III deficiency. Therefore, before starting therapy should determine the activity of antithrombin III. Normal indicators of activity of antithrombin III in human plasma is 80% – 120%, with a decrease of activity below 70% increased risk of thrombosis. Thus, one should expect since the individual drug dosage to levels of antithrombin III in plasma during periods between the administration of the drug was at least 70%.
Typically, patients with congenital antithrombin III deficiency half life time of the drug is about 2.5 days. In acquired antithrombin III deficiency half-life is considerably less in the case of disseminated intravascular coagulation (DIC) may be reduced to a few hours.
The duration of therapy is variable and depends on the disease. In general, the use of anti-thrombin III may be terminated after normalization laboratory parameters and / or relief of clinical signs. However, following cessation of therapy must regularly monitor the level of antithrombin III for a sufficiently long time. For determination of antithrombin III in plasma before and during drug therapy, it is recommended to measure the activity of antithrombin III, for example with a chromogenic substrate (amidolytic method).

 

  1. Disseminated intravascular coagulation
    Dose Antithrombin III is calculated based on the determination of antithrombin III activity in the plasma of the patient prior to treatment and during therapy every 4-6 hours. The initial dose should be sufficient to achieve plasma levels corresponding to normal (80%) – 120%). Additional doses are needed if the antithrombin III activity decreased below 70%.
    The dose of antithrombin III is calculated as follows: 1 ME antithrombin III / kg body weight = increase of antithrombin III in plasma levels of 1%
    When using antithrombin III in combination with heparin, it should be into account that the anticoagulant effect of heparin is potentiated by antithrombin III (see. also “Interactions with other medicines” and “Warnings”).
  2. Other diseases with deficiency of antithrombin III
    The recommended starting dose for adults with an average body mass ME 1500. The maintenance dose is less than twice the initial and administered at intervals of 8 to 24 hours. However, the dosage should be adjusted taking into account the individual characteristics that can be determined only at the regular measurement of the activity of antithrombin III in the patient’s plasma.
    The required dosage of antithrombin III, in the absence of the ICE signs, calculated as follows:
    1 ME Antithrombin III / kg body weight = increase in antithrombin III in plasma at 2%

Preparation of solution :
After cooking, Antithrombin III solution must be used immediately. Opened vials should not be stored.

  1. Warm the vial closed with a solvent at room temperature (not above 37 ° C).
  2. Remove the protective caps from the vials of lyophilized powder and solvent (Fig. A) and disinfect the rubber stoppers on both vials.
  3. The bundled-sided needle with two fastened together with protective caps. Tear bond (Fig. B) by scrolling and remove a cap. Pierce the free end of the needle stopper of the vial with the solvent (Fig. C).
  4. Remove the protective cap from the other end of the double-sided needle, without touching the needle itself.
  5. Turn the bottle with the solvent and pierce the stopper of the vial of lyophilized powder free end of the needle (Fig. D), insert the needle about half the length. The solvent falls in a bottle with a powder under vacuum.
  6. Separate bottles, removing the needle from the vial with the powder (Fig. E). Easy rocking the vial accelerate dissolution of the powder.
  7. After complete dissolution of the powder to precipitate foam pierce the stopper of the vial with the prepared solution of needle-duct (Fig. F), which is included in the kit. Then remove the needle-duct.

The introduction of the resultant solution :
Remove the protective cover from the enclosed filter needle and attach the needle to the sterile disposable syringe. Dial the solution in the syringe (Fig. The G).
Remove the needle from the syringe and slowly (maximum speed of administration of 5 ml / min) enter the solution intravenously through the enclosed disposable needle (or system for transfusion).
If you use another solution preparation method, use an appropriate filter prevent undissolved protein particles or pieces of rubber stoppers (risk microemboli).

Side effects:
As with the introduction of other plasma products, there may be rare anaphylactoid or anaphylactic reactions. In the event of such reactions (eg, fever, rash, nausea, vomiting, asthma, anaphylactic shock) you must stop the introduction of the drug.
Mild reaction can be stopped by introducing antihistamines, severe reactions to the development of hypotension require conventional emergency antishock measures.

Cautions
Patients with hemorrhagic diathesis, joint use of antithrombin III and heparin increases the risk of bleeding. The use of antithrombin III in combination with heparin anticoagulant therapy enhances the effect of which should be taken into account when calculating doses of heparin. In addition, patients with thrombocytopenia must consider the possibility platelet factor 4 deficit leading to disruption neutralize heparin and thus to increase the risk of bleeding.
As a rule, in combination therapy with heparin should regularly monitor the activated partial thromboplastin time (APTT) and adjust the dose heparin. In a joint application with heparin dose of the latter should not exceed the ME 500.
In patients with congenital antithrombin III deficiency should be considered the possibility of holding an appropriate vaccination.

Interaction with other drugs

  • the joint application of heparin and antithrombin III, the last effect increases
  • pronounced deficiency of antithrombin III considerably reduces the effectiveness of heparin action.

release Form

  • bottle containing 500 ME lyophilized antithrombin III
  • a vial containing 10 ml of water for injections
  • set for preparation of the solution (expenditure needle, needle filter, needle adapter, the needle duct, infusion system).

in a cardboard box with instructions for use.

  • flask containing 1000 ME lyophilized antithrombin III
  • a vial containing 20 ml of water for injections
  • set for preparation of the solution (expenditure needle, needle filter, needle adapter, the needle duct, infusion system).

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Anadrol

anadroll

Pharmacodynamics anadroll has antianginal, anti-hypoxic action. Directly affecting cardiomyocytes and neurons in the brain, improves their metabolism and function. Cytoprotective effect is due to an increase in energy potential, activation of oxidative decarboxylation and rationalization of consumption of oxygen (increased aerobic glycolysis and fatty acid oxidation blockade). It supports myocardial contractility, prevents a decrease in intracellular ATP and phosphocreatine. The conditions of acidosis normalizes the functioning of membrane ion channels, prevents the accumulation of calcium and sodium in cardiomyocytes, normalizes intracellular concentration of potassium ions. Reduces intracellular acidosis and phosphate, caused by myocardial ischemia and reperfusion. Prevents the damaging action of free radicals, preserves the integrity of cell membranes, prevent neutrophil activation in the area of ischemia increases the electrical potential, reduces the yield of creatine kinase from the cells and the severity of ischemic myocardial damage. When angina reduces the frequency of attacks (reduced nitrate consumption), after 2 weeks of treatment increases exercise capacity, reduced blood pressure drops. Improves hearing and vestibular trial results in patients decreases dizziness and tinnitus. When vascular pathology eyes restores functional activity of the retina eyes.Pharmacokinetics After oral administration of anadroll is rapidly and almost completely absorbed from the gastrointestinal tract. Bioavailability – 90%. Time to reach maximum plasma concentration – 2 hours (maximum concentration after a single dose of 20 mg of anadroll about 55 ng / ml). Easily penetrates the blood-tissue barriers. The half-life (T ½ ) is 4.5-5 hours. Contact with blood plasma proteins – 16%. Report from the body by the kidneys (60% unchanged).

INDICATIONS

  • Ischemic heart disease: prevention of angina attacks (in the complex therapy);
  • Chorioretinal vascular disorders
  • Vertigo of vascular origin;
  • Cochle-vestibular disorders ischemic nature (tinnitus, hearing impairment).

CONTRAINDICATIONS

  • Hypersensitivity to any component of the drug;
  • Renal impairment (creatinine clearance less than 15 mL / min);
  • Severe hepatic dysfunction;
  • Pregnancy;
  • The period of breast-feeding;
  • Age 18 years (effectiveness and safety have been established).

DOSAGE AND ADMINISTRATION:
Inside, during a meal.
The recommended dosing regimen – 2-3 tablets (40-60 mg) per day, 2-3 hours. The course of treatment recommended by the doctor.

SIDE EFFECTS
: Allergic reactions (itchy skin). Rarely from the gastrointestinal tract: gastralgia, nausea, vomiting; headache, feeling of palpitations.

Overdose
Currently, cases of overdose have been reported.

VZAIMODEISTVIE DRUG
No information.

Cautions
Against the background of drug treatment in patients with coronary heart disease is a significant decrease in daily requirement of nitrates. Use of the drug has no effect on the ability to control the car and the performance of work requiring a high rate of mental and physical reactions.

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Anadrol_2

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Paracetamol It has analgesic anadrol 50mg and antipyretic action; eliminates headache and other types of pain, increased temperature reduces.

Ascorbic acid (vitamin C) involved in the regulation of redox processes, carbohydrate metabolism, improves the body’s resistance.

Anadrol 50mg  has anti-allergic effect, facilitates breathing through the nose, reducing the feeling of nasal congestion, sneezing, watery eyes, itching and reddening of the eyes.

INDICATIONS:

Infectious-inflammatory diseases (SARS, influenza), accompanied by fever, chills, headache, pain in joints and muscles, nasal congestion and sore throat and sinuses.

CONTRAINDICATIONS:

Hypersensitivity to paracetamol, ascorbic acid, anadrol 50mg or any other component of the formulation; erosive and ulcerative lesions of the gastrointestinal tract (exacerbation); severe renal and / or hepatic impairment; angle-closure glaucoma; child (up to 3 years);

Carefully – Kidney and / or liver failure, deficiency of glucose-6-phosphate dehydrogenase, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor), viral hepatitis.

DOSAGE AND ADMINISTRATION:

Inside. Children from 3 to 5 years 1/2 tablet 2 times a day; children from 5 to 10 years: 1 tablet 2 times a day; Children from 10 to 15 years: 1 tablet 2-3 times a day. The tablet should dissolve completely in a beaker (200 ml) with warm water (50-60 ° C) and the resulting solution immediately drink eminence labs. It is better to take the drug between meals. The interval between doses of the drug should be at least 4 hours.

Patients with impaired hepatic or renal function the interval between doses of biomex labs the drug should be at least 8 hours.

The duration of intake without consulting your doctor no more than 5 days in the appointment as an analgesic and 3 days as antipyretic.

 

SIDE EFFECTS:
The drug was well tolerated at recommended doses.

In a few cases occur: CNS : headache, fatigue, from the gastrointestinal tract : nausea, pain in the epigastric region, with the endocrine system : hypoglycemia (up to the development of coma), with the side of blood : anemia, hemolytic anemia (especially for patients with deficiency of glucose-6-phosphate dehydrogenase); rarely – thrombocytopenia, allergic reactions: skin rash, pruritus, urticaria, angioedema,Other: hypervitaminosis, metabolic disorder, sensation of heat, dry mouth, paresis of accommodation, urinary retention, drowsiness. About all the side effects of the drug should be reported to your doctor.

OVERDOSE:

Symptoms of an overdose of the drug due to its constituent materials. The clinical picture of acute paracetamol overdose develops within 6-14 hours after administration. Symptoms of chronic overdose appear within 2-4 days after the increase in dose. Symptoms of an acute overdose of paracetamol:diarrhea, loss of appetite, nausea and vomiting, abdominal discomfort and / or abdominal pain, increased sweating.
Symptoms of overdose anadrol 50mg: Dizziness, agitation, sleep disturbances, depression, convulsions.

Treatment: Symptomatic.

 

INTERACTION WITH OTHER DRUGS:

Ethanol enhances the sedative effect of antihistamines.
Antidepressants, antiparkinsonian agents, antipsychotic agents (phenothiazines) – increase the risk of side effects (urinary retention, dry mouth, constipation). Corticosteroids – increase the risk of developing glaucoma.

In an application reduces the chronotropic effect of isoprenaline.

It reduces the therapeutic effects of antipsychotic drugs (neuroleptics) – phenothiazine derivatives, tubular reasorbtsiyu amphetamine and tricyclic antidepressants.

Inductors microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which makes the possibility of severe intoxication with small overdoses. Ethanol contributes to the development of acute pancreatitis.

Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxicity. Simultaneous administration of the drug and increases the diflunisal concentration in blood plasma by 50% paracetamol, hepatotoxicity increases. Simultaneous administration of barbiturates, reduces the effectiveness of paracetamol increases the excretion of ascorbic acid in the urine.

Paracetamol reduces the effectiveness of uricosuric drugs.

SPECIAL INSTRUCTIONS:

When receiving metoclopramide, domperidone or cholestyramine also need to consult with your doctor.

With prolonged use at doses considerably higher than recommended, increasing the likelihood of human liver and kidneys, requires monitoring of peripheral blood picture.

Paracetamol and ascorbic acid can interfere with the performance of laboratory tests (quantitative determination of glucose and uric acid in blood plasma bilirubin, activity of “liver” transaminases, LDH).

Appointment of ascorbic acid in patients with rapidly proliferating and rapidly metastasizing tumors may increase during the process. In patients with a high content of iron in the body, ascorbic acid should be used in minimal doses. anabolic steroids online pharmacy

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Anadrol dosage is a concentrated solution of purified immunoglobulin fractions extracted by alcohol from the blood plasma of donors immunized with recombinant anadrol dosage B vaccine. Each donor plasma checked for the surface antigen of anadrol dosage B virus (HBsAg) and antibodies to HIV-1 and HIV-2 and HCV protein concentration in the formulation from 10 to 16%. The concentration of antibodies to surface antigen of anadrol dosage B virus is not less than 50 IU / ml. The product does not contain a preservative or antibiotics.
Transparent or slightly opalescent liquid, colorless or with a faint yellow color. During storage may be the appearance of a slight precipitate white, disappearing with shaking at room temperature.

Immunological properties . Are active principles of the drug antibody to the surface antigen of anadrol dosage B virus (HBsAg), the virus that block receptors. The maximum concentration of antibody in the blood after 24 hours, the period of half-life of 4-5 weeks.

Appointment . Emergency prevention of anadrol dosage B in children and adults; treatment of light and medium-severe forms of acute viral anadrol dosage B in adults.

Dosage and Administration . Immunoglobulin is administered by intramuscular injection into the upper outer quadrant of the gluteal muscles or in the outer thigh.Prior to drug injection ampoule is kept for 2 hours at room temperature. Opening of ampoules and injection procedure is carried out in strict compliance with the rules of aseptic and antiseptic. The drug is in the opened ampoule can not be stored. Not suitable for the use of drugs in vials with impaired integrity or marking a change of physical properties (color change, turbidity, the presence of non-separating sludge), with an expired shelf life, if not properly stored. To avoid the formation of foam formulation in a syringe needle with a wide clearance.

Prevention . The dose and frequency of administration depends on the indication for use:

  • newborns from mothers – HBsAg carriers or patients with acute anadrol dosage B in the period of delivery is administered 1 dose (100 ME) in the first 12 hours after birth simultaneously with anadrol dosage B vaccine, but in different areas of the body (in the future children to be vaccination vaccine anadrol dosage B age 1, 2 and 12 months);
  • individuals not vaccinated before anadrol dosage B or those in whom vaccination is not finished, or when the level of HBs-antibody below protective (<10 IU / l) after accidental infection through contact with infectious material (for injections, dental manipulation, blood transfusion, infected material splashes in the mouth or eyes, etc.), the drug is administered at the rate of 0.1 ml / kg body weight as soon as possible after exposure (preferably within 24-48 hours.).
    at the same time ( on the same day) to start anadrol dosage B vaccination scheme 0-1-2-12 months. or to continue the initiated course. persons belonging to a high risk of anadrol dosage B virus infection with group B (centers, patients of chronic hemodialysis patients suffering from various diseases, which for health reasons receive frequent transfusions of blood and blood products, contact in the outbreaks of anadrol dosage B et al.), are not vaccinated against anadrol dosage B , immunoglobulin is administered prior to the procedure – hemodialysis, transfusion of blood and blood products, etc .; Children up to 10 years – 100 ME, children older than 10 years and adults – at the rate of 0.1 ml / kg body weight. Simultaneously with the introduction of immunoglobulin should begin a course of vaccination against anadrol dosage B for a shorter circuit – 3 vaccine applications at intervals of 1 month. At 12 months after the start of immunization is administered 4th extra dose of vaccine. The first dose of the vaccine is administered simultaneously with immune globulin, but in different parts of the body.
    When the use of the drug in a volume of more than 5 ml of the prescribed dose is recommended to enter in different parts of the gluteus maximus.
    The drug is used only by a physician (medical assistant).Introduction immunoglobulin registered in the established registration form indicating the batch number, production date, expiry date, the manufacturer, the date of administration, dose, infusion reactions.Treatment . With the purpose of treatment Antigep ® – human anadrol dosage B immune globulin administered during the first five days of the onset of jaundice period anadrol dosage V.Preparat administered in a single dose of 0.1 ml / kg body weight, daily for 3 days.Reactions to the introduction , as a rule, lacking. In rare cases, the reaction may develop in the form of local congestion, raising the temperature to 37,5 ° C during the first day after administration. In individuals with altered reactivity may develop allergic reactions of various types, and in extremely rare cases – anaphylactic shock, and therefore the person who received the drug should be under medical supervision for 30 minutes. Locations of vaccination must be provided by means of anti-shock therapy.Contraindications . Contraindicated administration of human anadrol dosage B immunoglobulin against persons who had a history of severe allergic reactions to human blood products.
    With a history of clinically significant allergic reactions to day administration of immunoglobulin and in the next 3 days, it recommended the appointment of antihistamines. Persons suffering immunopathological systemic diseases (diseases of the blood, connective tissue, jade, etc.), the drug should be administered on a background of appropriate therapy.Caution . Vaccination against measles, mumps and rubella is performed not earlier than 2 months after the administration of human immunoglobulin against anadrol dosage B.